BRCA Testing

For women with ovarian cancer, early identification of BRCA mutations can help determine the most appropriate treatment plan, and if the mutation is germline, can also support identification of family members at risk, and reduce future cancers through potential interventions.1–3

Whilst germline BRCA testing for women with ovarian cancer is now commissioned by NHS England, funding for tumour BRCA testing remains limited.4,5 Therefore, to support identification of these women, AstraZeneca is providing a tumour BRCA testing service  at certain sites in the UK for patients who meet the eligibility criteria.

Here you can find out more about BRCA testing, what the AstraZeneca tumour BRCA testing service is and how you can access it.

Importance of BRCA testing women with ovarian cancer

BRCA testing can help define treatment for women with ovarian cancer, as well as identify at risk family members.
Identifying BRCA gene mutations can have huge implications both for the patient and for society:

  • It can provide prognostic information – women with BRCAm have longer treatment free intervals and respond differently to platinum-based chemotherapy1
  • It can open up treatment options – which can offer the chance of a longer period of progression free survival for patients with relapsed disease. One example of such a treatment is Lynparza (olaparib) capsules*1,2
  • It can also allow for predictive genetic testing and advice about screening and risk reductive surgery to be given to at risk family members if the mutation is found to be germline – to minimise their chance of developing breast and/or ovarian cancer3

*Lynparza capsules are indicated as monotherapy for the maintenance treatment of adult patients with platinum-sensitive relapsed BRCA-mutated (germline and/or somatic) high grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete response or partial response) to platinum-based chemotherapy.2

For more information on Lynparza capsules, visit the Lynparza page here.