LynparzaTM (olaparib) is a first‐in‐class PARP inhibitor (PARPi) that allows women with BRCA mutated (BRCAm) platinum‐sensitive relapsed high-grade serous ovarian cancer to extend progression‐free survival (PFS).1-3
About BRCA Testing
Are you currently testing for BRCAm status?
Any woman with ovarian cancer could have a BRCA mutation21, 22
Genetic testing should be offered to a woman with ovarian cancer if her combined BRCA1 and BRCA2 mutation carrier probability is 10% or more.
– NHS England Commissioning policy E01/P/b, July 201516
NHS England states that genetic testing should be offered to all women with ovarian cancer with a combined BRCA1 and BRCA2 mutation carrier probability of 10% or more.16 As approximately 20% of women with high-grade serous ovarian cancer carry a BRCA gene mutation,36 this means that all women with high-grade serous ovarian cancer should be tested for BRCAm. This also aligns with NICE guidance (all women with ≥10% risk of carrying BRCAm)15, and that provided by BGCS (all women with high-grade serous or Grade 3 endometrioid cancer).17
BRCAm status is critical for the identification of patients with ovarian cancer suitable for Lynparza.4
- Limited information on the incidence of BRCAm in the platinum-sensitive relapsed setting is available. Combined data from two individual studies suggest that about: 30-40% patients with platinum-sensitive relapsed ovarian cancer are considered to possibly have BRCAm disease.3, 22
- Knowing every woman’s BRCAm status at diagnosis of ovarian cancer allows for timely personalised treatment decisions that can improve outcomes.14, 38
- Patients with BRCAm ovarian cancer are likely to have increased sensitivity to platinum-based therapy compared to BRCA wild-type patients.3