LOKELMATM Sodium Zirconium Cyclosilicate

SWIFT* K+ REDUCTION AFTER ONE HOUR.1,2
SUSTAINED K+ CONTROL FOR UP TO ONE YEAR
WHEN USED AS A MAINTENANCE THERAPY.†1
NOW IN YOUR HANDS.
New, highly-selective LOKELMA (sodium zirconium cyclosilicate)
is indicated for the treatment of hyperkalaemia in adult patients1

*In an emergency situation, standard of care should be used in line with local or national guidelines
Clinical trials with LOKELMA have not included exposure longer than one year

Product Information

About LOKELMA

  • For adult patients with hyperkalaemia, LOKELMA (sodium zirconium cyclosilicate) is highly selective and proven
    to significantly reduce potassium (K+) levels after 1 hour*1,2
  • 88% of patients achieved normokalaemia at 48 hours1
  • Once-daily maintenance dosing of LOKELMA sustains normokalaemia (3.5 - 5.0 mmol/L) for up to one year†1

*In an emergency situation, standard of care should be used in line with local or national guidelines.
Clinical trials with LOKELMA have not included exposure longer than 1 year.

Mechanism of Action

Novel, selective K+ capture3

LOKELMA captures K+ throughout the entire gastrointestinal (GI) tract and reduces the concentration of free K+ in the GI lumen, thereby increasing faecal K+ excretion to reduce serum levels of K+.1

Lattice structure uniquely designed to preferentially capture K+3

  • LOKELMA is a non-absorbed, non-polymer inorganic powder with a uniform micropore structure that preferentially captures K+ in exchange for Hydrogen and Sodium cations (Na+)1
  • LOKELMA is highly selective for K+ ions, even in the presence of other cations, such as Calcium (Ca+) and Magnesium (Mg2+), in vitro‡1
  • LOKELMA contains less than 8% Na+ by total weight. For example, one 5 g dose of LOKELMA contains 400 mg of Na+3 

      ‡In vitro data suggest LOKELMA works at different pHs found along the GI tract.

 

LOKELMA<sup>TM</sup> micropore structure that captures K+ to treat hyperkalaemia
LOKELMA<sup>TM</sup> micropore structure that captures K+ to treat hyperkalaemia

Adapted from Stavros F, et al. PLoS One. 2014;9(12):e114686.

  • Not systemically absorbed1
  • No effect on serum calcium or magnesium concentrations1
  • No effect on urinary Na+ excretion1